Human TGF-beta1-Mammalian

产品名称：  Human TGF-beta1-Mammalian|Recombinant Human TGF-β1 (mammalian derived)
供应商：  PeproTech
规格： 5ug
目录价： 2340
库存状态： 现货  
种属来源： 人
相关信息： Recombinant Human TGF-β1 (mammalian derived)|现货进口
Cross Reactivity:
They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. Chicken, Cow, Dog, Frog, Monkey, Mouse, Pig, Rabbit, Rat. Country of Origin: USA
Biological Activity:
Human TGF-β1 is a 25.0 kDa protein with each subunit containing 112 amino acid residues, linked by a single disulfide bond. The ED50 was determined by TGF-beta1s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg. Source: HEK293 cells
Description:
The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing.